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From gene presence to function
Can we conclude from gene presence to presence of activity/function?
Information about gene activity can be extracted from the sequence
Analysis
Task 1: The CE8 pectinase
Let's start by inspecting the feature architecture of the CE8 pectinase in the invertebrate Bradysia coprophila.
- Find the row in the phylogenetic profile that contains the orthologs of the pectinase CE8_QRW20161.1
- Find the dot that represents the ortholog in the invertebrate Bradysia coprophila
- Click on the corresponding dot and display the detailed plot
- Select XP_037045633.1 and click on 'show domain architecture'
- Which domains do you find annotated?
Task 2: The GH28 glycosyl hydrolase
This time, let's start by inspecting the feature architecture of the GH28 Glycosyl-hydrolase in the fungus Rhizoctonia solani.
- Find the dot that corresponds to the GH28_QRW23661.1 in Rhizoctonia solani
- Inspect the domain plot and note which domains are annotated.
- Have a look at the available information about the Glyco_hydro_28 domain
- Now, find the domain plot for the ortholog in the invertebrate Bradysia coprophila
- What differences do you observe?