===== Biodiverse genome assemblies =====

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How do we explain the sporadic presence of orthologs in a clade?
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**Assumption:** All detected genes are encoded in the genome of the respective species
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==== Analysis ====

In this module, we will analyse the orthologs of the GH28 glycosyl hydrolase in the two invertebrates //Bradysia coprophila// and //Spodoptera litura// in more detail. 

=== Task 1: Spodoptera litura ===

  * Find the NCBI accession ID of the GH28_QRW23661.1 in //Spodoptera litura// using the [[https://ebersberger-46-155.biologie.uni-frankfurt.de/phyloppcd/|interactive webviewer]]<WRAP 200px><hidden Spoiler>
[[https://www.ncbi.nlm.nih.gov/protein/XP_022836218.1?report=genpept|XP_022836218.1]]
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  * Perform a [[https://blast.ncbi.nlm.nih.gov/Blast.cgi?PAGE=Proteins|BLASTp search]] against the "Non-redundant protein sequences (nr)" database
  * Take a look at the list of best hits. Which taxonomic clade do they represent?


=== Task 2: Bradysia coprophila ===

  * Repeat the analysis with the GH28_QRW23661.1 ortholog in //Bradysia coprophila//<WRAP 200px><hidden Spoiler>
[[https://www.ncbi.nlm.nih.gov/protein/XP_037031340.1]]
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=== Summary and Discussion ===

  * Note down your observation and discuss with the group



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