October 4–7 | Frankfurt, Germany

Nicole T. Perna, J.F. Crow Institute for the Study of Evolution, University of Wisconsin-Madison, USA


Navigating Incongruence and Uncertainty in Genome-scale Phylogenetic and Ancestral State Reconstructions of Enterobacteria

A robust phylogenetic framework is a cornerstone of evolutionary analyses that illuminates myriad biological questions. Extensive horizontal gene transfer in some groups of bacteria can be a significant confounding factor in detection of a predominant phylogenetic history representing even the majority of a given set of genomes. Regions of the genomes or individual genes with alternate evolutionary histories can also provide biological insights. Taxon sampling biases and inherent data limitations for individual genes can make it challenging to distinguish between true incongruence and uncertainty. Here, we present comparative genomic analyses of enterobacteria, a ubiquitous model family with members free-living in soil, water and air, and associated with hosts as diverse as humans and potatoes. Through a combination of orthology prediction, gene-by-gene, total evidence, coalescent-based, and quartet-based approaches to phylogenetic reconstruction, coupled with inferences on ancestral genome content, metabolic and regulatory networks, we dissect the genome-wide evolutionary history of enterobacteria with the ultimate goal of understanding the emergence of complex traits such as host-range, pathogenicity and responses to abiotic environmental parameters like oxygen availability.

Contact/ Imprint

Responsible Organizing Chair

Prof. Dr. Ingo Ebersberger

Goethe-University Frankfurt/Main
Department for Applied Bioinformatics
Institute for Cell Biology and Neuroscience

Max-von-Laue Str. 13
D-60438 Frankfurt

Contact Email

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Program Committee

Max Alekseyev (Washington, DC, USA)
Lars Arvestad (Stockholm, Sweden)
Anne Bergeron (Montreal, Canada)
Marília D. V. Braga (Rio de Janeiro, Brazil)
Cedric Chauve (Vancouver, Canada)
Ingo Ebersberger (Frankfurt, Germany)
Nadia El-Mabrouk (Montreal, Canada)
Guillaume Fertin (Nantes, France)
Katharina Jahn (Basel, Switzerland)
Asif Javed (Singapore)
Jens Lagergren (Stockholm, Sweden)
Zsuzsanna Lipták (Verona, Italy)
Veli Mäkinen (Helsinki, Finland)
Ketil Malde (Bergen, Norway)
Aoife McLysaght (Dublin, Ireland)
João Meidanis (Campinas, Brazil), co-chair
Bernard Moret (Lausanne, Switzerland)
Istvan Miklos (Budapest, Hungary)
Aida Ouangraoua (Lille, France)
Teresa Przytycka (Bethesda, USA)
Marie-France Sagot (Lyon, France)
Michael Sammeth (Rio de Janeiro, Brazil)
João Setubal (Sao Paulo, Brazil)
Jens Stoye (Bielefeld, Germany), co-chair
Krister Swenson (Montpellier, France)
Eric Tannier (Lyon, France)
Glenn Tesler (San Diego, USA)
Tamir Tuller (Tel Aviv, Israel)
Lusheng Wang (Hong Kong)
Tandy Warnow (Illinois, USA)
Sophia Yancopoulos (New York, USA)
Louxin Zhang (Singapore)
Chunfang Zheng (Ottawa, Canada)
Jie Zheng (Singapore)

Organizing Committee

Ingo Ebersberger (Frankfurt, Germany), chair
Julia Krohmer (Frankfurt, Germany)

Steering Committee

Jens Lagergren (Stockholm, Sweden)
Aoife McLysaght (Dublin, Ireland)
David Sankoff (Ottawa, Canada)

Isobel Parkin, Agriculture et Agroalimentaire Canada, Saskatoon, Canada

Impacts of polyploidy on genome evolution in Brassica species

The triangle of U describes the relationship between six species of the Brassica genus, where three lower chromosome number species (Brassica rapa, Brassica oleracea and Brassica nigra) have hybridized in all combinations to generate three allopolyploid species (Brassica napus, Brassica juncea and Brassica carinata). Each of the lower chromosome number species are paleopolyploids having evolved through multiple rounds of genome duplication and subsequent diploidisation. Complete genome sequences have been generated for each of these Brassica species and comparative analyses among them are facilitated by alignment to a common ancestral Brassicaceae genome. The relationship among these species offers a unique opportunity to study the impact of multiple polyploidisation events on the evolution of genome structure, in particular maintenance or fractionation of duplicated gene complements, the potential for homoeologous chromosomal exchange in the allopolyploid species, and the consequent influence of these events on adaptive traits.

General Program Information

This page enlists a detailed time schedule for each day of the conference.

Registration Information

The registration fee includes the welcome reception, lunch on Monday 5th and Tuesday 6th, as well as public transportation in Frankfurt for the duration of the conference. The costs for the conference dinner are not covered.

Early Registration

Price (EUR)
Regular registration 250
Post-Doc* 200
Student / PhD Student* 160
Conference Dinner 45

Late Registration

Price (EUR)
Regular registration 300
Post-Doc* 250
Student/PhD Student* 210
Conference Dinner closed

* You will need to provide us with a copy of your valid student card or a letter from your institution confirming your status as a student / Post-Doc.

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All cancellations must be sent in writing and addressed to recomb2015 ‘at’ Cancellation of registration received up to and including August 4th 2015 will be subject to a 15% cancellation fee. No refunds will be given after August 4th, 2015.Transfer of registration fee to another delegate is accepted without charge for the identical registration category. All refunds will be processed after the end of the conference.

Cancelation received by August 4th 2015: 15% cancelation fee
Cancelation received thereafter: no refund.

The conference has ended. Registrations are no longer possible.