Pfefferle, K., Lopalco, P., Breisch, J., Siemund, A., Corcelli, A., Averhoff, B. (2020) In vivo synthesis of monolysocardiolipin and cardiolipin by Acinetobacter baumannii phospholipase D and effect on cationic antimicrobial peptide resistance. Environ. Microbiol. 22 : 5300-5308.

Hubloher, J.J., Zeidler, S., Lamosa, P., Santos H., Averhoff, B., Müller, V. (2020) Trehalose-6-phosphate mediated phenotypic change in Acinetobacter baumannii. Environ. Microbiol. 22 : 5156-5166.

König, P., Averhoff, B., Müller, V. (2020) A first response to osmostress in Acinetobacter baumannii: transient accumulation of K+ and its replacement by compatible solutes. Environ. Microbiol. Rep. 12 : 419-423.

Breisch, J., Averhoff, B. (2020) Identification of osmo-dependent and osmo-independent betaine-choline-carnitine transporters in Acinetobacter baumannii: role in osmostress protection and metabolic adaptation. Environ. Microbiol. 22 : 2724-2735.

Zeidler, S., Müller, V. (2020) Unusual deprivation of compatible solutes in Acinetobacter baumannii. Environ. Microbiol. 22 : 1370-1380.



Gerson, S., Betts, J.W., Lucaßen, K., Nodari, C.S., Wille, J., Josten, M., Göttig, S., Nowak, J., Stefanik, D., Roca, I., Vila, J., Cisneros, J.M., La Ragione, R.M., Seifert, H., Higgins, P.G. (2019) Investigation of novel pmrB and eptA mutations in isogenic Acinetobacter baumannii isolates associated with colistin resistance and increased virulence In Vivo. Antimicrob. Agents Chemother. 63 : e01586-18

Zeidler, S., Müller, V. (2019) Coping with low water activities and osmotic stress in Acinetobacter baumannii: significance, current status and perspectives. Environ. Microbiol. 21 : 2212-2230

Runci, F., Gentile, V.,Frangipani, E., Rampioni, G., Leoni, L., Lucidi, M., Visaggio, D., Harris, G., Chen, W., Stahl, J., Averhoff, B., Visca, P. (2019) The contribution of active iron-uptake to Acinetobacter baumannii pathogenicity. Infect. Immun. 25 : 87.

Foong, W. E., Tam, H.-K., Crames, J., Averhoff, B., Pos, K.M. (2019) The chloramphenicol/H+antiporter CraA of Acinetobacter baumannii AYE reveals a broad substrate specificity. J. Antimicrob. Chemother. 74 : 1192-1201.


Gerson, S., Nowak, J., Zander, E., Ertel, J., Wen, Y., Krut, O., Seifert, H., Higgins, P.G., (2018) Diversity of mutations in regulatory genes of resistance-nodulation-cell division efflux pumps in association with tigecycline resistance in Acinetobacter baumannii. J. Antimicrob. Chemother. 73 : 1501-1508

Higgins, P.G., Hrenovic, J., Seifert, H., Dekic, S. (2018) Characterization of Acinetobacter baumannii from water and sludge line of secondary wastewater treatment plant. Water Res. 140 : 261-267

Godeux, A., Lupo, A., Haenni, M., Guette-Marquet, S., Wilharm, G., Laaberki, M.H., Charpentier, X. (2018) Fluorescence-based detection of natural transformation in drug-resistant Acinetobacter baumannii. J. Bacteriol. 200 : e00181-18

Breisch, J., Waclawska, I., Averhoff, B. (2018). Identification and characterization of a carnitine transporter in Acinetobacter baumannii, MicrobiologyOpen : e752

Zeidler, S., Müller, V. (2018) The role of compatible solutes in desiccation resistance of Acinetobacter baumannii. MicrobiologyOpen : e740.

Blaschke, U., Suwono, B., Zafari. S., Ebersberger, I., Skiebe, E., Jeffries, C.M., Svergun, D.I., Wilharm, G. (2018) Recombinant production of A1S_0222 from Acinetobacter baumannii ATCC 17978 and confirmation of its DNA-(adenine N6)-methyltransferase activity. Protein Expr. Purif. 151 : 78-85

Blaschke, U., Skiebe, E., Kaatz, M., Higgins, P.G., Pfeifer, Y., Wilharm, G. (2018) Complete Genome Sequencing of Acinetobacter sp. Strain LoGeW2-3, Isolated from the Pellet of a White Stork, Reveals a Novel Class D Beta-Lactamase Gene. Genome Announc. 6 : e01405-17

Zeidler, S., Hubloher, J., König, P., Ngu, N.D., Scholz, A., Averhoff, B., Müller, V. (2018) Salt induction and activation of MtlD, the key enzyme in the synthesis of the compatible solute mannitol in Acinetobacter baumannii. Microbiology Open : e00614


Wen, Y., Ouyang, Z., Yu, Y., Zhou, X., Pei, Y., Devreese, B., Higgins, P.G., Zheng, F. (2017) Mechanistic insight into how multidrug resistant Acinetobacter baumannii response regulator AdeR recognizes an intercistronic region. Nucleic Acids Res. 45 : 9773-9787

Nowak, J., Zander, E., Stefanik, D., Higgins, P.G., Roca, I., Vila, J., McConnell, M.J., Cisneros, J.M., Seifert, H., MagicBullet Working Group WP4 (2017) High incidence of pandrug-resistant Acinetobacter baumannii isolates collected from patients with ventilator-associated pneumonia in Greece, Italy and Spain as part of the MagicBullet clinical trial. J. Antimicrob. Chemother. 72 : 3277-3282

Zeidler, S., Hubloher, J., Schabacker, K., Lanosa, P., Santos, H., Müller, V. (2017) Trehalose, a temperature- and salt-induced solute with implications in pathophysiology of Acinetobacter baumannii. Environ. Microbiol. 19 : 5088-5099

Wilharm, G., Skiebe, E., Higgins, P.G., Poppel, M.T., Blaschke, U., Leser, S., Heider, C., Heindorf, M., Brauner, P., Jäckel, U., Böhland, K., Cuny, C., Lopinska, A., Kaminski, P., Kasprzak, M., Bochenski, M., Ciebiera, O., Tobólka, M., Zolnierowicz, K.M., Siekiera, J., Seifert, H., Gagné, S., Salcedo, S.P., Kaatz, M., Layer, F., Bender, J.K., Fuchs, S., Semmler, T., Pfeifer Y., Jerzak, L. (2017) Relatedness of wildlife and livestock avian isolates of the nosocomial pathogen Acinetobacter baumannii to lineages spread in hospitals worldwide. Environ. Microbiol. 19: 4349-4364

Nicholas, T., Wolff, H., Djahanschiri, B., Grundmann, F., Kronenwerth, M., Shi, Y., Simonyi, S., Grün, P., Shapiro-Ilan, D., Pidot, S., Stinear, T., Ebersberger, I., Helge Bode, H. (2017) Natural product diversity associated with the nematode symbionts Photorhabdus and Xenorhabdus. Nature Microbiology, doi: 10.1038/s41564-017-0039-9.

Higgins, P.G., Prior, P., Harmsen, D., Seifert, H. (2017) Development and evaluation of a core genome multilocus typing scheme for whole-genome sequence-based typing of Acinetobacter baumannii. PLoS One 12 : e0179228

Evans, S.R., Hujer, A.M., Jiang, H., Hill, C.B., Hujer, K.M., Mediavilla, J.R., Manca, C., Tran, T.T., Domitrovic, T.N., Higgins, P.G., Seifert, H., Kreiswirth, B.N., Patel, R., Jacobs, M.R., Chen, L., Sampath, R., Hall, T., Marzan, C., Fowler, V.G. Jr., Chambers, H.F., Bonomo, R.A.; Antibacterial Resistance Leadership Group (ARLG) (2017) Informing antibiotic treatment decisions: evaluating rapid molecular diagnostics (RMDs) to identify susceptibility and resistance to carbapenems against Acinetobacter spp. PRIMERS III. J. Clin. Microbiol. 55: 134-144

Lopalco, P., Stahl, J., Annese, C., Averhoff, B., Corcelli, A. (2017) Identification of unique cardiolipin and monolysocardiolipin species in Acinetobacter baumannii. Scientific Reports 7, doi:10.1038/s41598-017-03214-w

Blaschke, U., Wilharm, G. (2017) Complete genome sequence of Acinetobacter sp. strain NCu2D-2 isolated from a mouse. Genome Announc. 5 : e01415-16

Scheich, S., Lindner, S., König, R., Reinheimer, C., Wichelhaus, T.A:, Hogardt, M., Kempf, V.A.J., Kessel, J., Martin, H., Wilke, A., Serve, H., Bug, G., Steffen, B. (2017) Clinical impact of colonization with multidrug-resistant organisms on outcome after allogeneic stem cell transplantation in patients with acute myeloid leukemia. Cancer, in press.

Mücke, M.M., Rumyantseva, T., Mücke, V.T., Sosnowsky, K., Kempf, V.A.J., Welsch, C., Zeuzem, C., Lange, C.M. (2017) Bacterial infection-triggered acute-on-chronic liver failure is associated with increased mortality. Liver Int., in press.

Mücke, M.M., Kessel, J., Mücke, V.T., Sosnowsky, K., Hogardt, M., Stephan, C., Zeuzem, S., Kempf, V.A.J., Lange, C.M. (2017) The role of Enterococcus spp. and multidrug-resistant bacteria causing pyogenic liver abscesses. BMC Infect. Dis., in press.

Ferstl, P., Filmann, N., Brandt, C., Zeuzem, S., Hogardt, M., Kempf, V.A.J., Waidmann, O., Reinheimer, C. (2017) The impact of carbapenem resistance on clinical deteriorationand mortality in patients with liver disease. Liver Int., in press.

Reinheimer, C., Keppler, O.T., Stephan, C., Wichelhaus, Friedrichs, I., Kempf, V.A.J. (2017) Elevated prevalence of multidrug-resistant gram-negative organisms in HIV positive men. BMC Infect. Dis., in press.

Reinheimer, C., Kempf, V.A.J. (corresponding author), Jozsa, K., Wichelhaus, T.A., Hogardt, M., Brandt, C. (2017) Prevalence of multidrug-resistant organisms in refugee patients, medical tourists and domestic patients admitted to a German University Hospital. BMC Infect. Dis. 17: 17

Klotz, P.*, Göttig, S.*, Leidner, U., Semmler, T., Scheufen, S., C. Ewers (2017) Carbapenem-resistance and pathogenicity of bovine Acinetobacter indicus-like isolates. PLoS ONE 12 : e0171986. *equal contribution to this paper.


Göttig, S., Riedel-Christ, S., Saleh, A., Kempf, V.A., A. Hamprecht (2016) Impact of blaNDM-1 on fitness and pathogenicity of Escherichia coli and Klebsiella pneumoniae. Int. J. Antimicrob. Agents. 47: 430-435

Nowak, J., Schneiders, T., Seifert, H., Higgins, P.G. (2016) The Asp20-to-Asn substitution in the response regulator AdeR leads to enhanced efflux activity of AdeB in Acinetobacter baumannii. Antimicrob. Agents Chemother. 60 : 1085-1090

Zander, E., Seifert, H., Higgins, P.G. (2016) Effects of saline, an ambient acidic environment, and sodium salicylate on OXA-mediated carbapenem resistance in Acinetobacter baumannii. Antimicrob. Agents Chemother. 60 : 3415-3418

Komp Lindgren, P., Higgins, P.G., Seifert, H., Cars, O. (2016) Prevalence of hypermutators among clinical Acinetobacter baumannii isolates. J. Antimicrob. Chemother. 71 : 661-665

Lytvynenko, I., Brill, S., Oswald, C., Pos, K.M.* (2016) Molecular basis of polyspecificity of the small multidrug resistance efflux pump AbeS from Acinetobacter baumannii. J. Mol. Biol. 428 : 644-657

Higgins, P.G., Chan, J.Z.-M., Pallen, M.J., Seifert, H., Millard, A.D. (2016) Draft genome sequence of 11 clinical isolates of Acinetobacter baumannii. Genome announcement 4 : e00269-16

Vargiu, A.V., Pos, K.M., Poole, K., Nikaido, H. (2016) Bad Bugs in the XXIst Century: Resistance Mediated by Multi-Drug Efflux Pumps in Gram-Negative Bacteria. Front Microbiol. 7 : 833

Poppel, M.T., Skiebe, E., Laue, M., Bergmann, H., Ebersberger, I., Garn, T., Fruth, A., Baumgardt, S., Busse, H.J., Wilharm, G. (2016) Acinetobacter equi sp. nov. isolated from horse faeces. Int. J. Syst. Evol. Microbiol. 66 : 881-888

Koenigs, A., Stahl, J., Averhoff, B., Göttig, S., Wichelhaus, T.A., Wallich, R., Zipfel, P.F., Kraiczy, P. (2016) CipA of Acinetobacter baumannii is a novel plasminogen and complement binding protein. J. Infect. Dis. 213 : 1388-1399

Scholz, A., Stahl, J., de Berardinis, V., Müller, V., Averhoff, B. (2016) Osmotic stress response in Acinetobacter baylyi: Identification of a glycine-betaine biosynthesis pathway and regulation of osmoadaptive choline uptake and glycine betaine synthesis through a choline-responsive BetI repressor. Environ. Microbiol. Reports 8 : 316-322


Nowak, J., Schneiders, T., Seifert, H., Higgins, P.G. (2015) The Asp20-to-Asn Substitution in the Response Regulator AdeR Leads to Enhanced Efflux Activity of AdeB in Acinetobacter baumannii. Antimicrob. Agents Chemother. 60 : 1085-1090

Nowak, J., Seifert, H., Higgins, P.G. (2015) Prevalence of eight RND-efflux pump genes in epidemiologically characterised Acinetobacter baumannii of worldwide origin. J. Med. Microbiol. 64 : 630-635

Weidensdorfer, M., Chae, J.I., Makobe, C., Stahl, J., Averhoff, B., Müller, V., Schürmann, C., Brandes, R., Wilharm, G., Ballhorn, W., Christ, S., Linke, D., Fischer, D., Göttig, S., Kempf, V. (2015) Analysis of endothelial adherence of Bartonella henselae and Acinetobacter baumannii using a dynamic human ex vivo infection model. Infect. Immun. 84 : 711-722

Stahl, J., Bergmann, H., Göttig, S., Ebersberger, I., Averhoff, B. (2015) Acinetobacter baumannii virulence is mediated by the concerted action of three phospholipases D. PLoS ONE 10 : e0138360

Nemec, A., Krizova, L., Maixnerova, M., Sedo, O., Brisse, S., Higgins, P.G. (2015) Acinetobacter seifertii sp. nov., a member of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex isolated from human clinical specimens. Int. J. Syst. Evol. Microbiol. 65 : 934-942

Averhoff, B. (2015) Acinetobacter baumannii – understanding and fighting a new emerging pathogen. Environ. Microbiol. 7 : 6-8

Waidmann, O., Kempf, V.A., Brandt, C., Zeuzem, S., Piiper, A., Kronberger, B. (2015) Colonisation with multidrug-resistant bacteria is associated with increased mortality in patients with cirrhosis. Gut 64 : 1183-1184

Sand, M., Rodrigues, M., Gonzalez, J.M., de Crecy-Lagard, V., Santos, H., Müller, V., Averhoff, B. (2015) Mannitol-1-phosphate dehydrogenases/phosphatases: a family of novel bifunctional enzymes for bacterial adaptation to osmotic stress. Environ. Microbiol. 17 : 711-719


Göttig, S., Gruber, T.M., Higgins, P.G., Wachsmuth, M., Seifert, H., Kempf, V.A. (2014) Detection of pan drug-resistant Acinetobacter baumannii in Germany. J. Antimicrob. Chemother. 69 : 2578-2579

Sand, M., Stahl, J., Waclawska, I., Ziegler, C., Averhoff, B. (2014) Identification of an osmo-dependent and an osmo-independent choline transporter in Acinetobacter baylyi: implications in osmostress protection and metabolic adaptation. Environ. Microbiol. 16 : 1490-1502

Zander, E., Bonnin, R. A., Seifert, H., Higgins, P.G. (2014) Characterization of blaOXA-143 variants in Acinetobacter baumannii and Acinetobacter pittii. Antimicrob. Agents. Chemother. 58 : 2704-2708

Zander, E., Seifert, H., Higgins, P.G. (2014) Insertion sequence IS18 mediates overexpression of blaOXA-257 in a carbapenem-resistant Acinetobacter bereziniae isolate. J. Antimicrob. Chemother. 69 : 270-271

Heindorf, M., Kadari, M., Heider, C., Skiebe, E., Wilharm, G. (2014) Impact of Acinetobacter baumannii superoxide dismutase on motility, virulence, oxidative stress resistance and susceptibility to antibiotics. PLoS One 9 : e101033

Kleinkauf, N., Hausemann, A., Kempf, V.A., Gottschalk, R., Heudorf, U. (2014) Burden of carbapenem-resistant organisms in the Frankfurt/Main Metropolitan Area in Germany 2012/2013 – first results and experiences after the introduction of legally mandated reporting. BMC Infect. Dis. 14 : 446

Zander, E., Fernández-González, A., Schleicher, X., Dammhayn, C., Kamolvit, W., Seifert, H., Higgins, P.G. (2014) Worldwide dissemination of acquired carbapenem-hydrolysing class D & beta-lactamases in Acinetobacter spp. other than Acinetobacter baumannii. Int. J. Antimicrob. Agents 43 : 375-377

Hischebeth, G.T., Wimmer, M.D., Molitor, E., Seifert, H., Gravius, S., Bekeredjian-Ding, I. (2014) Multidrug resistant Acinetobacter baumannii reaches a new frontier: prosthetic hip joint infection. Infection 43 : 95-97

Müller, V., Kempf, V.A.J. (2014) Acinetobacter baumannii – ein Pathogen mit zunehmender Bedeutung. Biospektrum 20 : 703


Wilharm, G., Piesker, J., Laue, M., Skiebe, E. (2013) DNA uptake by the nosocomial pathogen Acinetobacter baumannii occurs during movement along wet surfaces. J. Bacteriol. 195 : 4146-4153

Higgins, P.G., Perez-Llarena, F.J., Zander, E., Fernandez, A., Bou, G., Seifert, H. (2013) OXA-235, a novel class D beta-lactamase involved in resistance to carbapenems in Acinetobacter baumannii. Antimicrob. Agents. Chemother. 57 : 2121-2126

Proschak, A., Lubuta, P., Gruen, P., Loehr, F., Wilharm, G., De Berardinis, V., Bode, H. B. (2013) Structure and biosynthesis of fimsbactins A-F, siderophores from Acinetobacter baumannii and Acinetobacter baylyi. Chembiochem. 14 : 633-638

Schleicher, X., Higgins, P.G., Wisplinghoff, H., Koerber-Irrgang, B., Kresken, M., Seifert, H. (2013) Molecular epidemiology of Acinetobacter baumannii and Acinetobacter nosocomialis in Germany over a 5-year period (2005-2009). Clin. Microbiol. Infect. 19 : 737-742

Sand, M., Mingote, I., A., Santos, H., Müller, V., Averhoff, B. (2013) Mannitol, a compatible solute synthesized by Acinetobacter baylyi in a two-step pathway including a salt-induced and salt-dependent mannitol-1-phosphate dehydrogenase. Environ. Microbiol. 15 : 2187–2197

Zander, E., Chmielarczyk, A., Heczko, P., Seifert, H., Higgins, P.G. (2013) Conversion of OXA-66 into OXA-82 in clinical Acinetobacter baumannii isolates and association with altered carbapenem susceptibility. J. Antimicrob. Chemother. 68 : 308-311

Zander, E., Higgins, P.G., Fernández-González, A., Seifert, H. (2013) Detection of intrinsic blaOXA-51-like by multiplex PCR on its own is not reliable for the identification of Acinetobacter baumannii. Int. J. Med. Microbiol. 303 : 88-89

Choi, J.Y., Ko, G., Jheong, W., Huys, G., Seifert, H., Dijkshoorn, L., Ko, K.S. (2013) Acinetobacter kookii sp. nov., isolated from soil. Int. J. Syst. Evol. Microbiol. 63 : 4402–4406