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Source: mustervorlage.net

2017

Zeidler, S., Hubloher, J., Schabacker,K., Lanosa, P. Santos, H., Müller, V. (2017) Trehalose, a temperature- and salt-induced solute with implications in pathophysiology of Acinetobacter baumannii. Environ. Microbiol. 19 : 5088-5099.

Wilharm, G., Skiebe, E., Higgins, P.G., Poppel, M.T., Blaschke, U., Leser, S., Heider, C., Heindorf, M., Brauner, P., Jäckel, U., Böhland, K., Cuny, C., Lopinska, A., Kaminski, P., Kasprzak, M., Bochenski, M., Ciebiera, O., Tobólka, M., Zolnierowicz, K.M., Siekiera, J., Seifert, H., Gagné, S., Salcedo, S.P., Kaatz, M., Layer, F., Bender, J.K., Fuchs, S., Semmler, T., Pfeifer Y., Jerzak, L. (2017) Relatedness of wildlife and livestock avian isolates of the nosocomial pathogen Acinetobacter baumannii to lineages spread in hospitals worldwide. Environ. Microbiol. 19: 4349-4364.

Nicholas, T., Wolff, H., Djahanschiri, B., Grundmann, F., Kronenwerth, M., Shi, Y., Simonyi, S., Grün, P., Shapiro-Ilan, D., Pidot, S., Stinear, T., Ebersberger, I., Helge Bode, H. (2017) Natural product diversity associated with the nematode symbionts Photorhabdus and Xenorhabdus. Nature Microbiology, doi: 10.1038/s41564-017-0039-9.

Higgins, P.G., Prior, P., Harmsen, D., Seifert, H. (2017) Development and evaluation of a core genome multilocus typing scheme for whole-genome sequence-based typing of Acinetobacter baumannii. PLoS One. 2017. 12:e0179228

Evans, S.R., Hujer, A.M., Jiang, H., Hill, C.B., Hujer, K.M., Mediavilla, J.R., Manca, C., Tran, T.T., Domitrovic, T.N., Higgins, P.G., Seifert, H., Kreiswirth, B.N., Patel, R., Jacobs, M.R., Chen, L., Sampath, R., Hall, T., Marzan, C., Fowler, V.G. Jr., Chambers, H.F., Bonomo, R.A.; Antibacterial Resistance Leadership Group (ARLG) (2017) Informing antibiotic treatment decisions: evaluating rapid molecular diagnostics (RMDs) to identify susceptibility and resistance to carbapenems against Acinetobacter spp. PRIMERS III. J. Clin. Microbiol. 55: 134-144

Lopalco, P., Stahl, J., Annese, C., Averhoff, B., Corcelli, A. (2017) Identification of unique cardiolipin and monolysocardiolipin species in Acinetobacter baumannii. Scientific Reports 7, doi:10.1038/s41598-017-03214-w

Blaschke, U., Wilharm, G. (2017) Complete genome sequence of Acinetobacter sp. strain NCu2D-2 isolated from a mouse. Genome Announc. 5:e01415-16

Scheich, S., Lindner, S., König, R., Reinheimer, C., Wichelhaus, T.A:, Hogardt, M., Kempf, V.A.J., Kessel, J., Martin, H., Wilke, A., Serve, H., Bug, G., Steffen, B. (2017) Clinical impact of colonization with multidrug-resistant organisms on outcome after allogeneic stem cell transplantation in patients with acute myeloid leukemia. Cancer, in press.

Mücke, M.M., Rumyantseva, T., Mücke, V.T., Sosnowsky, K., Kempf, V.A.J., Welsch, C., Zeuzem, C., Lange, C.M. (2017) Bacterial infection-triggered acute-on-chronic liver failure is associated with increased mortality. Liver Int., in press.

Mücke, M.M., Kessel, J., Mücke, V.T., Sosnowsky, K., Hogardt, M., Stephan, C., Zeuzem, S., Kempf, V.A.J., Lange, C.M. (2017) The role of Enterococcus spp. and multidrug-resistant bacteria causing pyogenic liver abscesses. BMC Infect. Dis., in press.

Ferstl, P., Filmann, N., Brandt, C., Zeuzem, S., Hogardt, M., Kempf, V.A.J., Waidmann, O., Reinheimer, C. (2017) The impact of carbapenem resistance on clinical deteriorationand mortality in patients with liver disease. Liver Int., in press.

Reinheimer, C., Keppler, O.T., Stephan, C., Wichelhaus, Friedrichs, I., Kempf, V.A.J. (2017) Elevated prevalence of multidrug-resistant gram-negative organisms in HIV positive men. BMC Infect. Dis., in press.

Reinheimer, C., Kempf, V.A.J. (corresponding author), Jozsa, K., Wichelhaus, T.A., Hogardt, M., Brandt, C. (2017) Prevalence of multidrug-resistant organisms in refugee patients, medical tourists and domestic patients admitted to a German University Hospital. BMC Infect. Dis. 17: 17.

Klotz, P.*, Göttig, S.*, Leidner, U., Semmler, T., Scheufen, S., C. Ewers (2017) Carbapenem-resistance and pathogenicity of bovine Acinetobacter indicus-like isolates. PLoS ONE. 12:e0171986. *equal contribution to this paper.

2016

Göttig, S., Riedel-Christ, S., Saleh, A., Kempf, V.A., A. Hamprecht (2016) Impact of blaNDM-1 on fitness and pathogenicity of Escherichia coli and Klebsiella pneumoniae. Int. J. Antimicrob. Agents. 47: 430-435.

Nowak, J., Schneiders, T., Seifert, H., Higgins, P.G. (2016) The Asp20?Asn substitution in the response regulator AdeR leads to enhanced efflux activity of AdeB in Acinetobacter baumannii. Antimicrob Agents Chemother 60 : 1085-1090

Zander, E., Seifert, H., Higgins, P.G. (2016) Effects of saline, an ambient acidic environment, and sodium salicylate on OXA-mediated carbapenem resistance in Acinetobacter baumannii. Antimicrob Agents Chemother. 60 : 3415-3418

Komp Lindgren, P., Higgins, P.G., Seifert, H., Cars, O. (2016) Prevalence of hypermutators among clinical Acinetobacter baumannii isolates. J. Antimicrob. Chemother. 71 : 661-665

Lytvynenko, I., Brill, S., Oswald, C., Pos, K.M.* (2016) Molecular basis of polyspecificity of the small multidrug resistance efflux pump AbeS from Acinetobacter baumannii. J. Mol. Biol. 428 : 644-657

Higgins, P.G., Chan, J.Z.-M., Pallen, M.J., Seifert, H., Millard, A.D. (2016) Draft genome sequence of 11 clinical isolates of Acinetobacter baumannii. Genome announcement 4 : e00269-16

Vargiu, A.V., Pos, K.M., Poole, K., Nikaido, H. (2016) Bad Bugs in the XXIst Century: Resistance Mediated by Multi-Drug Efflux Pumps in Gram-Negative Bacteria. Front Microbiol. 7 : 833

Poppel, M.T., Skiebe, E., Laue, M., Bergmann, H., Ebersberger, I., Garn, T., Fruth, A., Baumgardt, S., Busse, H.J., Wilharm, G. (2016) Acinetobacter equi sp. nov. isolated from horse faeces. Int. J. Syst. Evol. Microbiol. 66 : 881-888

Koenigs, A., Stahl, J., Averhoff, B., Göttig, S., Wichelhaus, T.A., Wallich, R., Zipfel, P.F., Kraiczy, P. (2016) CipA of Acinetobacter baumannii is a novel plasminogen and complement binding protein. J. Infect. Dis. 213 : 1388-1399

Scholz, A., Stahl, J., de Berardinis, V., Müller, V., Averhoff, B. (2016) Osmotic stress response in Acinetobacter baylyi: Identification of a glycine-betaine biosynthesis pathway and regulation of osmoadaptive choline uptake and glycine betaine synthesis through a choline-responsive BetI repressor. Environ. Microbiol. Reports 8 : 316-322

2015

Nowak, J., Seifert, H., Higgins, P.G. (2015) Prevalence of eight RND-efflux pump genes in epidemiologically characterised Acinetobacter baumannii of worldwide origin. J. Med. Microbiol. 64 : 630-635

Weidensdorfer, M., Chae, J.I., Makobe, C., Stahl, J., Averhoff, B., Müller, V., Schürmann, C., Brandes, R., Wilharm, G., Ballhorn, W., Christ, S., Linke, D., Fischer, D., Göttig, S., Kempf, V. (2015) Analysis of endothelial adherence of Bartonella henselae and Acinetobacter baumannii using a dynamic human ex vivo infection model. Infect. Immun. 84 : 711-722

Stahl, J., Bergmann, H., Göttig, S., Ebersberger, I., Averhoff, B. (2015) Acinetobacter baumannii virulence is mediated by the concerted action of three phospholipases D. PLoS ONE 10: e0138360

Nemec, A., Krizova, L., Maixnerova, M., Sedo, O., Brisse, S., Higgins, P.G. (2015) Acinetobacter seifertii sp. nov., a member of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex isolated from human clinical specimens. Int. J. Syst. Evol. Microbiol. 65 : 934-942

Averhoff, B. (2015) Acinetobacter baumannii – understanding and fighting a new emerging pathogen. Environ. Microbiol. 7 : 6-8

Waidmann, O., Kempf, V.A., Brandt, C., Zeuzem, S., Piiper, A., Kronberger, B. (2015) Colonisation with multidrug-resistant bacteria is associated with increased mortality in patients with cirrhosis. Gut 64 : 1183-1184

Sand, M., Rodrigues, M., Gonzalez, J.M., de Crecy-Lagard, V., Santos, H., Müller, V., Averhoff, B. (2015) Mannitol-1-phosphate dehydrogenases/phosphatases: a family of novel bifunctional enzymes for bacterial adaptation to osmotic stress. Environ. Microbiol. 17 : 711-719

2014

Göttig, S., Gruber, T.M., Higgins, P.G., Wachsmuth, M., Seifert, H., Kempf, V.A. (2014) Detection of pan drug-resistant Acinetobacter baumannii in Germany. J. Antimicrob. Chemother. 69 : 2578-2579

Sand, M., Stahl, J., Waclawska, I., Ziegler, C., Averhoff, B. (2014) Identification of an osmo-dependent and an osmo-independent choline transporter in Acinetobacter baylyi: implications in osmostress protection and metabolic adaptation. Environ. Microbiol. 16 : 1490-1502

Zander, E., Bonnin, R. A., Seifert, H., Higgins, P.G. (2014) Characterization of blaOXA-143 variants in Acinetobacter baumannii and Acinetobacter pittii. Antimicrob. Agents. Chemother. 58 : 2704-2708

Zander, E., Seifert, H., Higgins, P.G. (2014) Insertion sequence IS18 mediates overexpression of blaOXA-257 in a carbapenem-resistant Acinetobacter bereziniae isolate. J. Antimicrob. Chemother. 69 : 270-271

Heindorf, M., Kadari, M., Heider, C., Skiebe, E., Wilharm, G. (2014) Impact of Acinetobacter baumannii superoxide dismutase on motility, virulence, oxidative stress resistance and susceptibility to antibiotics. PLoS One 9, e101033

Kleinkauf, N., Hausemann, A., Kempf, V.A., Gottschalk, R., Heudorf, U. (2014) Burden of carbapenem-resistant organisms in the Frankfurt/Main Metropolitan Area in Germany 2012/2013 – first results and experiences after the introduction of legally mandated reporting. BMC Infect. Dis. 14 : 446

Zander, E., Fernández-González, A., Schleicher, X., Dammhayn, C., Kamolvit, W., Seifert, H., Higgins, P.G. (2014) Worldwide dissemination of acquired carbapenem-hydrolysing class D & beta-lactamases in Acinetobacter spp. other than Acinetobacter baumannii. Int. J. Antimicrob. Agents 43 : 375-377

Hischebeth, G.T., Wimmer, M.D., Molitor, E., Seifert, H., Gravius, S., Bekeredjian-Ding, I. (2014) Multidrug resistant Acinetobacter baumannii reaches a new frontier: prosthetic hip joint infection. Infection 43 : 95-97

Müller, V., Kempf, V.A.J. (2014) Acinetobacter baumannii – ein Pathogen mit zunehmender Bedeutung. Biospektrum 20 : 703

2013

Wilharm, G., Piesker, J., Laue, M., Skiebe, E. (2013) DNA uptake by the nosocomial pathogen Acinetobacter baumannii occurs during movement along wet surfaces. J. Bacteriol. 195 : 4146-4153

Higgins, P.G., Perez-Llarena, F.J., Zander, E., Fernandez, A., Bou, G., Seifert, H. (2013) OXA-235, a novel class D beta-lactamase involved in resistance to carbapenems in Acinetobacter baumannii. Antimicrob. Agents. Chemother. 57 : 2121-2126

Proschak, A., Lubuta, P., Gruen, P., Loehr, F., Wilharm, G., De Berardinis, V., Bode, H. B. (2013) Structure and biosynthesis of fimsbactins A-F, siderophores from Acinetobacter baumannii and Acinetobacter baylyi. Chembiochem. 14 : 633-638

Schleicher, X., Higgins, P.G., Wisplinghoff, H., Koerber-Irrgang, B., Kresken, M., Seifert, H. (2013) Molecular epidemiology of Acinetobacter baumannii and Acinetobacter nosocomialis in Germany over a 5-year period (2005-2009). Clin. Microbiol. Infect. 19 : 737-742

Sand, M., Mingote, I., A., Santos, H., Müller, V., Averhoff, B. (2013) Mannitol, a compatible solute synthesized by Acinetobacter baylyi in a two-step pathway including a salt-induced and salt-dependent mannitol-1-phosphate dehydrogenase. Environ. Microbiol. 15 : 2187–2197

Zander, E., Chmielarczyk, A., Heczko, P., Seifert, H., Higgins, P.G. (2013) Conversion of OXA-66 into OXA-82 in clinical Acinetobacter baumannii isolates and association with altered carbapenem susceptibility. J. Antimicrob. Chemother. 68 : 308-311

Zander, E., Higgins, P.G., Fernández-González, A., Seifert, H. (2013) Detection of intrinsic blaOXA-51-like by multiplex PCR on its own is not reliable for the identification of Acinetobacter baumannii. Int. J. Med. Microbiol. 303 : 88-89

Choi, J.Y., Ko, G., Jheong, W., Huys, G., Seifert, H., Dijkshoorn, L., Ko, K.S. (2013) Acinetobacter kookii sp. nov., isolated from soil. Int. J. Syst. Evol. Microbiol. 63 : 4402–4406

PhD Theses

  • Nowak, Jennifer. 2017. Prevalence of resistance-nodulation-cell division-type efflux pumps and their contribution to antimicrobial resistance in Acinetobacter baumannii. University of Cologne (H. Seifert/P. Higgins).
  • Daume, Thiemo. 2017. Analyse der Bindung von Komplementregulatoren an Biofilm von Acinetobacter baumannii und Komplement-inaktivierende Aktivität verschiedener Carbapenemasen. Goethe-Universität Frankfurt (P. Kraiczy).
  • Makobe, Celestine. 2016. Analysis of Acinetobacter baumannii pathogenicity mediated by the Acinetobacter Trimeric Autotransporter Adhesin (Ata). Goethe-Universität Frankfurt (V. Kempf).
  • Lytvynenko, Iryna. 2016. Molecular basis of polyspecificity of the small multidrug resistance efflux pump AbeS from Acinetobacter baumannii. Goethe-Universität Frankfurt (K.M. Pos).
  • Sand, Miriam. 2016. Adaptation of Acinetobacter species to dry environments. Goethe-Universität Frankfurt (B. Averhoff).
  • Waclawska, Izabela. 2016. BCCT-Family: Dynamics in stress-regulated betaine transport and role of pathogen-relevant choline transport. Goethe-Universität Frankfurt (C. Ziegler).
  • Koenigs, Arno. 2015. Interaktionen von Acinetobacter baumannii mit Plasminogen und Komplement. Goethe-Universität Frankfurt (V. Kempf/S. Göttig).
  • Zander, Esther. 2015. Distribution and genetic composition of carbapenem-resistance determinants in clinical Acinetobacter isolates – focus on carbapenem-hydrolysing beta-lactamases. University of Cologne (H. Seifert/P. Higgins).

Master Theses

  • König, Patricia. 2018. Untersuchungen zur Rolle von Kaliumionen in der Physiologie und Pathobiologie von Acinetobacter baumanii, Goethe-Universität Frankfurt (V. Müller)
  • Pfefferle Katharina. 2018. Funktionelle Analyse der Phospholipase D3 aus Acinetobacter baumannii, Goethe-Universität Frankfurt (B. Averhoff)
  • Ngu, Ngoc Dinh. 2017. Heterologe Produktion und Charakterisierung der bifunktionalen Mannitol-1-phosphat-Dehydrogenase/-Phosphatase aus Acinetobacter baumannii. Goethe-Universität Frankfurt (V. Müller)
  • Hubloher, Josephine. 2017. Reportergenstudien zur Analyse der transkriptionellen Regulation von mtlD und otsAB in Acinetobacter baumannii. Goethe-Universität Frankfurt (V. Müller)
  • Nouri, Noura. 2017. Analyse zur Komplement-inhibitorischen Kapazität des CipA Proteins von Acinetobacter baumannii. Goethe-Universität Frankfurt (P. Kraiczy).
  • Andresen, Silke. 2017. Funktionelle Analysen der Phospholipasen D aus Acinetobacter baumannii, Goethe-Universität Frankfurt (B. Averhoff).
  • Breisch, Jennifer. 2017. Charakterisierung der Betain/Cholin/Carnitin-Transporter aus Acinetobacter baumannii, Goethe-Universität Frankfurt (B. Averhoff).
  • Hirth, Niklas. 2017. Funktionelle Analysen des Oberflächenproteins PilY1 von Acinetobacter baumannii, Goethe-Universität Frankfurt (B. Averhoff).
  • Siemund, Anna. 2017. Analysen zur Regulation der Phospholipasen D in Acinetobacter baumannii, Goethe-Universität Frankfurt (B. Averhoff).
  • Schnakenberg, Annika. 2016. Funktionale Analysen der Phospholipasen C aus Acinetobacter baumannii. Goethe-Universität Frankfurt (B. Averhoff).
  • Reinig, Inga. 2016. Insights into the evolution of bacterial NRPS clusters, Goethe-Universität Frankfurt (I. Ebersberger).
  • Xanthopoulou, Kyriaki. 2015. Investigation of the differential expression of the Acinetobacter baumannii porins CarO, Omp33-36 kDa and OprD in response todifferent physiological conditions. University of Cologne (H. Seifert/P. Higgins).
  • Weidensdorfer, Marko. 2014. Etablierung eines neuartigen ex vivo Organinfektions­modells zur Analyse der Adhärenz von Bartonella henselae unter Verwendung menschlicher Nabelschnurvenen. Goethe-Universität Frankfurt (V. Kempf/S. Göttig).

Bachelor Theses

  • de Kruijff, Maritinus. 2018. Funktionale Analysen der Betain-/Cholin-/Carnitin-Transporter aus Acinetobacter baumannii, Goethe-Universität Frankfurt (B. Averhoff).
  • Gür, Melissa. 2017. Analysen der BCC-Transporter aus Acinetobacter baumannii, Goethe-Universität Frankfurt (B. Averhoff).
  • Ries, Julia. 2017. Interaktion von CipA Proteins aus Acinetobacter baumannii mit Komplement-komponenten. Goethe-Universität Frankfurt (P. Kraiczy).
  • Bärthlein, Nina. 2016. Strukturuntersuchungen am Cholin-Transporter BetT1 aus Acinetobacter baumannii. Universität Regensburg (C. Ziegler).
  • Bezzenberger, Lisa. 2016. Reinigung und biochemische Charakterisierung der Phospholipase A aus Acinetobacter baumannii, Goethe-Universität Frankfurt (B. Averhoff).
  • Bremer, Frederick. 2016. Verbesserung der Expression und Kristallisation des BCCT Betain und Ectoin Transporters LcoP. Universität Regensburg (C. Ziegler).
  • Gollek, Henrick. 2016. Tracing the Phylogenetic Profile of Acinetobacter baylyi’s Competence Machinery, Goethe-Universität Frankfurt (I. Ebersberger).
  • König, Patricia. 2016 Reportergenstudien und biochemische Untersuchungen zur Regulation des Typ-VI-Sekretionsapparates und der Mannitol-Dehydrogenase: Zwei potentielle Pathogenitätsfaktoren in Acinetobacter baumannii, Goethe-Universität Frankfurt (V. Müller).
  • Pfefferle, Katharina. 2016. Funktionale Analysen der prozessierten Phospholipasen C aus Acinetobacter baumannii, Goethe-Universität Frankfurt (B. Averhoff).
  • Pompe, Karoline. 2016. Characterisation of carbapenem-resistant Acinetobacter baumannii of different origin. University of Cologne (H. Seifert/P. Higgins).
  • Präve, Leonard. 2016. Charakterisierung von Substratspezifitätsdeterminanten in Acinetobacter baumannii AbeS. Goethe-Universität Frankfurt (K.M. Pos).
  • Schmidt, Daniel. 2016. Etablierung eines dynamischen humanen ex vivo Organinfektionsmodells zur Analyse der von Bartonella henselae und Acinetobacter baumannii induzierten Wirtszellantwort, Goethe-Universität Frankfurt (V. Kempf/S. Göttig).
  • Weber, Kristin. 2016. Vergleichende Untersuchungen zu den Untereinheiten der Sulfitreduktase in verschiedenen Acinetobacter baumannii-Stämmen, Brandenburgische Technische Universität Cottbus-Senftenberg (G. Wilharm).
  • Wohra, Sonali. 2016. Carbapenem-Resistenz in Acinetobacter spp.: Identifizierung und Charakterisierung einer neuen Klasse D Beta-Laktamase, Goethe-Universität Frankfurt (V. Kempf/S. Göttig).
  • Dosch, Julian. 2015. A Greedy approach for resolving overlapping domain architectures in FACT, Goethe-Universität Frankfurt (I. Ebersberger).
  • Hirth, Niklas. 2015. Analysen zur Regulation der Adaptation an Salzstress von Acinetobacter baylyi, Goethe-Universität Frankfurt (B. Averhoff).
  • Misak, Marcel. 2015. Gene order analysis in the human pathogen Acinetobacter baumannii, Goethe-Universität Frankfurt (I. Ebersberger).
  • Moissl, Benedikt. 2015. Cholin-Transport in Acinetobacter. Universität Regensburg (C. Ziegler).
  • Plum, Miro. 2015. Environmental sampling and screening for carbapenmases. University of Cologne (H. Seifert/P. Higgins).
  • Devant, Jessica. 2014. Cholin-Transporter der BCCT-Familie. Goethe-Universität Frankfurt (C. Ziegler).
  • Kaempffe, Anna. 2014. Rolle der Phospholipasen C aus Acinetobacter baumannii in metabolischer Adaptation und Virulenz, Goethe-Universität Frankfurt (B. Averhoff).
  • Schnakenberg, Annika. 2014. Charakterisierung der Phospholipasen aus Acinetobacter baumannii, Goethe-Universität Frankfurt (B. Averhoff).
  • Suwono, Beneditta. 2014. Characterization of A1S_0222 DNA adenine-methyltransferase in Acinetobacter baumannii, Westfälische Wilhelms-Universität Münster (G. Wilharm).

Welcome to the website of the DFG funded research unit 2251: Adaptation and persistence of the emerging pathogen Acinetobacter baumannii

Acinetobacter baumannii is a well-adapted hospital pathogen and recent data from the National Nosocomial Surveillance System (NNIS) showed a substantial increase in the number of cases of A. baumannii-associated nosocomial (hospital acquired) pneumonia, causing 5 – 10% of intensive care unit (ICU)-acquired pneumonia cases in the United States. Moreover, A. baumannii ranks 10th among the most frequent organisms (1.3%) causing monomicrobial nosocomial bloodstream infections in the US and 2 – 10% of nosocomial infections in intensive care units in European hospitals. The current knowledge concerning the physiological basis of A. baumannii virulence traits is rather limited. The persistence of A. baumannii is attributed to multiple factors but, unfortunately, knowledge regarding the molecular basis for these traits of A. baumannii, i.e. proteins, enzymes and genes involved as well as their regulation by abiotic and biotic factors remains largely unknown. The recent rapid development of analytical and bioinformatic tools, genetic and biochemical technologies, structural analysis, cell culture and animal infection models, all available to the research unit, will allow to address fundamental questions concerning the adaptation and persistence of the nosocomial pathogen A. baumannii by investigating:

  1. the mechanisms of metabolic adaptation (P1, P2),
  2. the role of adhesion, invasion and surface-associated motility during infections (P3, P4),
  3. the molecular mechanisms underlying complement resistance (P5),
  4. the molecular basis and regulation of multidrug resistance (P6, P7)
  5. the evolutionary origin, the distribution, genetic, metabolic and virulence attributes of virulence genes and their contribution to the success of A. baumannii (P8)

We anticipate to elucidate the mechanisms of A. baumannii virulence and eukaryotic host cell adaptation from the cellular to the structural level employing advanced analytical tools and a broad spectrum of available molecular biological, biochemical, immunological techniques and bioinformatic tools as well as cutting-edge techniques such as static and dynamic flow infections and various in vitro and in vivo infection models. The research group will fill the gap of knowledge and use the findings to show ways how to combat this threatening emerging pathogen. German Research Foundation (DFG) reacted to the alarming lack of knowledge by founding a national research unit comprising eight expert teams from all over Germany, headed by Prof. Dr. Volker Müller and Prof. Dr. Volkhard Kempf from Goethe University Frankfurt am Main. The research unit comprises internationally recognized experts from different faculties of the Goethe University in Frankfurt am Main comprising medical and nonmedical microbiologists, biochemists and an applied bioinformaticist, the Max-Planck Institute of Biophysics in Frankfurt, the Robert-Koch Institute in Wernigerode, and the University of Cologne. The collaborative research effort will promote regional and transregional interactions between nonclinical and clinical research groups which is essential to successfully address the multiple factors underlying A. baumannii virulence. This is only possible in an interdisciplinary network of researchers.